10:00-13:00	Registration
11:30-12:00	Welcome by organisers
12:00-13:00	Keynote Lecture Eleonora Leucci (Department of Oncology, KU Leuven, Belgium) Contribution of lncRNAs to the generation of drug-tolerant persister cells
13:00-14:30	Lunch
Session 1: New mechanisms in RNA biology Chairs: Francesco Nicassio, Eleonora Leucci
14:30-14:55	Maria Musarra-Pizzo (Milan) RNA surveillance as a therapeutic target for MYC oncogenic activity
14:55-15:20	Francesca Losi (Modena) A family of lncRNAs relate FSHD to nucleolar architecture and protein synthesis
15:20-15:45	Chiara Finocchiaro (Genoa) A systematic interrogation of lncRNAs in the context of triple-negative breast cancer
15:45-16:15	Coffee break
Session 2: Methods and technologies in RNA Chairs: Francesco Nicassio, Gabriella Viero
16:15-17:00	Keynote Lecture Gabriella Viero (Institute of Biophysics of CNR, Trento, Italy) Unlocking ribosome heterogeneity: high-resolution genome-wide positional sequencing and its implications in disease research
17:00-17:25	Giulia Venturi (Bologna) 5.8S ribosomal RNA isoforms and ribosome heterogeneity
17:25-17:50	Valeria Famà (Milan) Nanodynamo quantifies the dynamics of RNA metabolism and reveals extensive coupling between steps of the RNA life cycle
17:50-18:30	Talks by companies Nicola Conci (siTOOLs) rRNA contamination in Ribo-Seq: origin, characteristics and mitigation strategies Beatrice Salvatori (Negedia) Multi-Omic RNA strategies for in-depth molecular analyses Pierluigi Tenca (Tema Ricerca) PacBio HiFi for bulk and single-Cell RNA-seq: precision without compromise
18:30-20:00	Poster Session with drinks
20:30-23:00	Dinner

Session 3: RNA regulation in disease and development Chairs: Alessia Ciarrocchi, Tito Panciera
9:00-9:45	Keynote Lecture Tito Panciera (University of Padua, Italy) Mechanobiology of YAP and TAZ in physiology and disease
9:45-10:10	Mila Gugnoni (Reggio Emilia) Linc00941: boosting cMYC translation for increased ribogenesis and protein synthesis in malignant pleural mesothelioma
10:10-10:35	Giulia Biancon (Milan) Investigating the role of RNP granules in splicing factor-mutant hematologic malignancies
10:35-11:00	Valeria Di Gioia (Milan) LINE1 elements are novel epigenetic players of T cell quiescence and exhaustion through phase separation
11:00-11:30	Coffee break
Session 4: Synthetic biology and new technologies Chairs: Velia Siciliano, Francesco Ricci
11:30-12:15	Keynote Lecture Francesco Ricci (Tor Vergata University of Rome, Italy) Synthetic DNA-based devices, switches and genes for clinical applications
12:15-12:40	Francesca Piro (Naples) Engineering synthetic post-transcriptional regulators to enable long-term efficacy of T cell-based therapies
12:40-13:05	Doaa Ali-Naffaa (Haifa, Israel) Synthetic mammalian RNA-based gene circuits for high fold change expression
13:05-13:30	Silvia Tucciarone (Lund, Sweden) Elucidating the Ψ epitranscriptome driving normal and malignant hematopoiesis
13:30-14:00	Poster Prizes and Closing Remarks

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Poster Session • 25 October • 18:30-20:00

P.1 Ayca Altay Benetti (Singapore)
Design and characterization of a new formulation for the delivery of COVID-19-mRNA vaccine to the nasal mucosa

P.2 Vito Amico (Rome)
Plant microRNAs: an unexpected anti-inflammatory activity in a cross-kingdom regulation

P.3 Ylenia Antonacci (Bari)
TRIM8: the master concertator in chemosensitivity recovery of cancer cells

P.4 Matteo Balestra (Milan)
The role of RNA and RNA-binding proteins in EGFR non-clathrin endocytosis

P.5 Silvia Belluti (Modena)
Cross-talk between NF-Y transcription factor and m6A epitanscriptomic regulators in colon cancer: molecular characterization and clinical relevance

P.6 Ilaria Brentari (Trento)
Optimizing RNA therapies for dementia using hiPSC-derived FTDP-17 neuronal model

P.7 Ilaria Bruno (Trento)
Automated small molecule screening reveals candidates for the correction of SMN-specific translational defects

P.8 Fabiana Calandra (Naples)
RNA-encoded incoherent feed forward loops for resource aware transgene expression

P.9 Davide Capuano (Bari)
Site-directed RNA editing for correcting point mutations causing fALS

P.10 Chiara Ceriani (Segrate)
Innovative and multidisciplinary approach for the identification of healthy aging biomarkers​

P.11 Arianna Coppola (Naples)
The lncRNA T-UCstem1 controls gastruloid development non-cell-autonomously through regulation of DKK1

P.12 Laura Cuoghi (Modena)
The transcription factor NF-Y participates in prostate cancer progression and response to androgen-deprivation therapy

P.13 Alessandro D'Agnelli (Genoa)
The NREP:miR-29b-3p axis fine-tunes cancer plasticity and Epithelial-to-Mesenchymal Transition (EMT)

P.14 Alessandro De Santis (Rome)
Targeting melanoma resistance with synthetic microRNA: a systems biology approach

P.15 Lucrezia De Santis (Rome)
Dissecting the role of non-coding RNAs in melanoma phenotype switching

P.16 Valentina Fantini (Reggio Emilia)
Unraveling NK Cell-Mediated Cytotoxicity in NSCLC

P.17 Valentina Fragliasso (Reggio Emilia)
HELLS: a dual-function regulator of gene expression in T-cell lymphomas

P.18 Petronilla Frugis (Bari)
Harnessing endogenous ADARs for correcting a pathogenic G>A point mutation in SBF1

P.19 Clarissa Gervasoni (Segrate)
Investigating the anti-cancer potential of natural bioactive molecules in triple-negative breast cancer

P.20 Alessandro Giammona (Segrate)
A novel strategy for glioblastoma treatment by natural bioactive molecules showed a highly effective anti-cancer potential

P.21 Aymone Gurtner (Rome)
Deciphering the crosstalk between miR-200C and NF-YA splicing in cancer cells

P.22 Carol Imbriano (Modena)
Alterations in NF-Y splicing enable the metabolic plasticity of colon cancer cells and foster dynamic interactions within the tumor niche

P.23 Stefano Leto (Bologna)
Enhancing gene delivery in NB-4 cells: overcoming transduction and selection challenges

P.24 Selene Mallia (Reggio Emilia)
MTAAT: A Novel Regulator of PD-L1 in T-cell Lymphoma 

P.25 Giulia Malpezzi (Modena)
Investigating thymidylate synthase interactions with its mRNA using optical tweezers and bicistronic assay techniques

P.26 Fabio Marcuccio (Milan)
Regulation of mRNA homeostasis by poly(A) binding proteins

P.27 Martina Nespoli (Segrate)
ROS involvement in the crosstalk between chaperone-mediated autophagy and ferroptosis: molecular and biochemical implications

P.28 Sabela Nikolli (Rome)
Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53/Dicer complex

P.29 Julien Ouvrard (Genoa)
The contribution of lncRNAs and m6A epitranscriptomic mark to the 3D chromatin hubs integrity in glioblastoma cancer stem cells

P.30 Christina Pagiatakis (Varese)
The lincRNA Chheaf-1 controls cardiomyocyte homeostasis through epigenetic regulation of the Rtn4 enhancer

P.31 Chiara Pellizzer (Milan)
The molecular rearrangement driven by miRNA675-5p inhibition promotes the overcome of resistance in human glioma and its in vitro visualization through confocal microscopy

P.32 Cecilia Perrucci (Trento)
TDP-43-dependent translation defects in ALS pathogenesis: ribosome reallocation as a mechanistic model

P.33 Alessandro Provenzani (Trento)
Deconvoluting C9Orf72 RAN translation in ALS via chemical genomic approach

P.34 Noemi Puccio (Modena)
Exploring lncRNA NEAT1 targeting strategy to tackle multiple myeloma

P.35 Sofia Remedia (Segrate)
Ferroptosis induction as a novel therapeutic strategy in human glioma: molecular reconstruction of its mechanism of action

P.36 Laura Rigon (Padua)
Development of a nanoparticle-mRNA therapy to enhance albumin production in experimental models of liver cirrhosis 

P.37 Sabrina Rizzolio (Turin)
axl-miR-214sponge chimeric aptamer as therapeutic tool to target BRAF inhibitor resistant melanomas

P.38 Paola Spadavecchia (Bari)
New insights into A-to-I RNA editing in ALS unveiled by a large screening of hundreds RNAseq data

P.39 Serena Torrini (Trieste)
The mutant p53 target miR30d dampens the cGAS/STING1/IFN-I pathway to suppress immune surveillance in breast cancer

P.40 Giada Tria (Genoa)
Unveiling gene regulatory networks (GRNs) in TNBC

P.41 Kiril Tuntevski (Genoa)
Dissecting the mechanism of piRNA biogenesis and function in adult somatic stem cells of the murine hippocampal niche

P.42 Camilla Ugolini (Milan)
Nanopore ReCappable Sequencing and direct RNA sequencing map SARS-CoV-2 5ʹ capping sites and identify multiple modification sites in subgenomic RNAs

P.43 Emanuele Vitale (Reggio Emilia)
Coding and non-coding: exploring the transcriptional cooperation between RUNX2 and RAIN in thyroid cancer